Recombinant Desmoglein-1 (DSG1) Antibody, Clone: [DSG1/8576R], Rabbit, Monoclonal

Produktübersicht

• Artikelname: Recombinant Desmoglein-1 (DSG1) Antibody, Clone: [DSG1/8576R], Rabbit, Monoclonal
• Artikelnummer: NBT-1828-RBM8-P1
• Hersteller Artikelnummer: 1828-RBM8-P1
• Alternativnummer: NBT-1828-RBM8-P1-100
• Hersteller: NeoBiotechnologies
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Recombinant human DSG1 protein
• Alternative Synonym: Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DSG1, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1

Produktbeschreibung

Recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family.vC OODesmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.vC OOWithin the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [DSG1/8576R]
• Molekulargewicht: 150kDa (precursor), 160kDa (mature)
• NCBI: 1828
• UniProt: Q02413
• Formulierung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Bilder

Formalin-fixed, paraffin-embedded human skin stained with Desmoglein-1 Recombinant Rabbit Monoclonal Antibody (DSG1/8576R).