EGFR (Epidermal Growth Factor Receptor) Antibody, IgG2a, Clone: [31G7 + GFR1195], Mouse, Monoclonal

Produktübersicht

• Artikelname: EGFR (Epidermal Growth Factor Receptor) Antibody, IgG2a, Clone: [31G7 + GFR1195], Mouse, Monoclonal
• Artikelnummer: NBT-1956-MSM6-P1
• Hersteller Artikelnummer: 1956-MSM6-P1
• Alternativnummer: NBT-1956-MSM6-P1-100
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: FC, IF, IHC
• Spezies Reaktivität: Human
• Immunogen: Human EGFR Purified from A431 cells (31G7), Recombinant human EGFR protein (GFR1195)
• Alternative Synonym: Erbb1, ERBB1, Errp, HER1, mENA, PIG61, Proto-oncogene c-ErbB-1, Receptor Tyrosine Protein Kinase, ErbB1, Urogastrone, wa2, Wa5

Produktbeschreibung

This MAb recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [31G7 + GFR1195]
• Molekulargewicht: ~170kDa (wild type) and ~145kDa (vIII variant)
• Isotyp: IgG2a
• NCBI: 1956
• UniProt: P00533
• Formulierung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1mg/ml.

Bilder

Formalin-fixed, paraffin-embedded human Placenta stained with EGFR Monoclonal Antibody (31G7 + GFR1195).