FOLH1 / PSMA (Prostate Epithelial Marker) Antibody, IgG2b, Clone: [FOLH1/2363], Mouse, Monoclonal

Produktübersicht

• Artikelname: FOLH1 / PSMA (Prostate Epithelial Marker) Antibody, IgG2b, Clone: [FOLH1/2363], Mouse, Monoclonal
• Artikelnummer: NBT-2346-MSM3-P1ABX
• Hersteller Artikelnummer: 2346-MSM3-P1ABX
• Alternativnummer: NBT-2346-MSM3-P1ABX-100
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: IHC, WB
• Spezies Reaktivität: Bovine, Canine, Human, Rat
• Immunogen: Recombinant human FOLH1 protein fragment (around aa 232-433) (exact sequence is proprietary)
• Alternative Synonym: Cell growth-inhibiting gene 27 protein (GIG27), Folate hydrolase 1 (FOLH1), Folylpoly-gamma-glutamate carboxypeptidase (FGCP), Glutamate carboxylase II (GCPII), Glutamate carboxypeptidase 2 (GCP2), Glutamate carboxypeptidase II Membrane glutamate carboxypeptidase N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1 or NAALADase), Prostate-specific membrane antigen (PSM or PSMA), Pteroylpoly-gamma-glutamate carboxypeptidase

Produktbeschreibung

Folate hydrolase 1 (FOLH1), also known as Prostate-specific membrane antigen (PSMA), is a type II transmembrane glycoprotein belonging to the M28 peptidase family. FOLH1 has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [FOLH1/2363]
• Molekulargewicht: 100kDa
• Isotyp: IgG2b
• NCBI: 2346
• UniProt: Q04609
• Formulierung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Antibody Type: Monoclonal Antibody

Anwendungsbeschreibung

• Anwendungsbeschreibung: Western Blot (0.5-2ug/ml),,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for

Bilder

SDS-PAGE Analysis Purified FOLH1 (PSMA) Mouse Monoclonal Antib

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with FOLH1 (PSMA) Mouse Monoclonal Antibody (FOLH1/2363). HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.

SDS-PAGE Analysis Purified FOLH1 (PSMA) Mouse Monoclonal Antibody (FOLH1/2363). Confirmation of Purity and Integrity of Antibody.

Western Blot Analysis of human LNCaP cell lysate using FOLH1 (PSMA) Mouse Monoclonal Antibody (FOLH1/2363).

Formalin-fixed, paraffin-embedded human prostate cancer stained with FOLH1 (PSMA) Mouse Monoclonal Antibody (FOLH1/2363).

IHC analysis of formalin-fixed, paraffin-embedded cow brain. Tissue stained using FOLH1/2363 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.

IHC analysis of formalin-fixed, paraffin-embedded rat kidney. Tissue stained using FOLH1/2363 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.

IHC analysis of formalin-fixed, paraffin-embedded dog kidney. Tissue stained using FOLH1/2363 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.

Analysis of Protein Array containing more than 19,000 full-length human proteins using FOLH1 (PSMA) Mouse Monoclonal Antibody (FOLH1/2363). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD&apos,s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD&apos,s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Western Blot Analysis of LNCaP lysate using FOLH1 (PSMA) Mouse Monoclonal Antibody (FOLH1/2363).

Western Blot Analysis of LNCaP lysate using FOLH1 (PSMA) Mouse Monoclonal Antibody (FOLH1/2363).