Recombinant fragment (around aa1-200) of human FOLR1 protein corresponding to the extracellular domain (exact sequence is proprietary)
Alternative Synonym:
DOM, PCWH, SOX10, SRY (sex determining region Y) box 10, SRY box containing gene 10, SRY related HMG box gene 10, Waardenburg syndrome type 2E(WS2E), WS4, Waardenburg syndrome type 4C (WS4C)
Folate receptor alpha (FR) is a membrane-bound protein that facilitates high-affinity folate transport, essential for cell metabolism, DNA synthesis, and repair, particularly in rapidly dividing cancer cells with increased folate demands. This receptor, encoded by the FOLR1 gene, employs a potocytosis mechanism that leads to both membranous and cytoplasmic localization and is selectively overexpressed in certain epithelial malignancies while remaining highly restricted in normal tissues. FR expression correlates with tumor stage and grade, suggesting a role in tumor progression by enhancing folate uptake or generating regulatory signals. Its regulation is influenced by extracellular folate levels, homocysteine accumulation, hormones, transcription factors, and genetic mutations. Members of the folate receptor family share highly conserved sequences in the open reading frames but differ in amino acids in the 5 untranslated regions and as a consequence can differ in function and tissue expression. Given the selective overexpression of FR in tumors and its association with aggressive cancer phenotypes, FR is a valuable marker for studying tumor biology and progression, particularly in epithelial cancers.
200ug/ml of Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified FOLR1 Recombinant Rabbit Monoclonal Antibody(FOLR1/13425R). Confirmation of Purity and Integrity of Antibody.
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