GATA-3 (Center) (Breast and Urothelial Marker) Antibody, IgG2b, Clone: [MSVA-450M], Mouse, Monoclonal

Produktübersicht

• Artikelname: GATA-3 (Center) (Breast and Urothelial Marker) Antibody, IgG2b, Clone: [MSVA-450M], Mouse, Monoclonal
• Artikelnummer: NBT-2625-MSM27-P1
• Hersteller Artikelnummer: 2625-MSM27-P1
• Alternativnummer: NBT-2625-MSM27-P1-100
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Recombinant full-length human GATA-3 protein
• Alternative Synonym: GATA binding protein-3, GATA-binding factor 3, HDR, HDRS, Transacting T-cell-specific transcription factor GATA-3

Produktbeschreibung

GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50kDa nuclear protein regulates the development and subsequent maintenance of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 involved in luminal cell differentiation in the mammary gland and appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 is associated with the expression of estrogen receptor-alpha (ER) in breast cancer. GATA-3 has been shown to be a novel marker for bladder cancer. The study demonstrated that GATA-3 stained 67% of urothelial Carcinomas, but none of prostate or renal carcinomas.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [MSVA-450M]
• Molekulargewicht: ~50kDa
• Isotyp: IgG2b
• NCBI: 2625
• UniProt: P23771
• Formulierung: Ab purified from Bioreactor Concentrate by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide.

Bilder

Trans-acting T-cell-specific transcription factor GATA-3 Mouse Monoclonal Antibody (MSVA-450M) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.