HLA-G (Major Histocompatibility Complex, class I, G) Antibody, Clone: [HLAG/7750], Mouse, Monoclonal
Artikelnummer:
NBT-3135-MSM10-P0
Hersteller Artikelnummer:
3135-MSM10-P0
Alternativnummer:
NBT-3135-MSM10-P0-20
Hersteller:
NeoBiotechnologies
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC, WB
Spezies Reaktivität:
Human
Immunogen:
Recombinant fragment (around aa1-200) of human HLAG protein (exact sequence is proprietary)
Alternative Synonym:
B2 microglobulin, DADB-15K14.8, HLA 6.0, HLA G histocompatibility antigen class I G, HLA G3, HLA60, HLAG, Major histocompatibility complex class I G, MHC class I antigen G, MHC G, T-cell A locus, TCA
Major histocompatibility complex (MHC), human leukocyte antigen (HLA) molecules are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an a or heavy chain, and a non-covalently associated protein, 2-microglobulin. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically 8-10 residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a noncovalent complex of an a and b chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified HLA-G Mouse Monoclonal Antibody (HLAG/7750). Confirmation of Purity and Integrity of Antibody.
Western blot analysis of JEG3 cell lysate using HLA-G Mouse Monoclonal Antibody (HLAG/7750).
Formalin-fixed, paraffin-embedded human kidney stained with HLA-G Mouse Monoclonal Antibody (HLAG/7750). Inset: PBS instead of primary antibody, secondary only negative control.
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