MR1 / Major histocompatibility complex, class I-related Antibody, IgG2, Clone: [MR1/7578], Mouse, Monoclonal
Artikelnummer:
NBT-3140-MSM2-P0
Hersteller Artikelnummer:
3140-MSM2-P0
Alternativnummer:
NBT-3140-MSM2-P0-20
Hersteller:
NeoBiotechnologies
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human
Immunogen:
Recombinant fragment (around aa50-250) of human MR1 protein (exact sequence is proprietary)
Alternative Synonym:
Class I histocompatibility antigen like protein, HLALS, Major histocompatibility complex class I like sequence, Major histocompatibility complex class I related isoform CRA a, MHC class I related gene protein, MHC class I related protein 1 isoform B, MR1B, MR1C
MR1 (major histocompatibility complex, class I-related), also known as HLALS, is a 341 amino acid single-pass membrane protein that localizes to the endoplasmic reticulum, as well as to the extracellular side of the cell membrane, and contains one Ig-like C1-type domain. Expressed ubiquitously, MR1 exists as a heterodimer with b-2-Microglobulin and plays an important role in antigen presentation, specifically in the development and expansion of mucosalassociated invariant T cells (MAITs). MAITs are located in the gut and are involved in monitoring flora levels, as well as in conveying distress signals to other areas of the body, indicating a role for MR1 in proper digestion and immune system function. MR1 exists as four alternatively spliced isoforms and is encoded by a gene which maps to human chromosome 1.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
