60kDa chaperonin, 60kDa heat shock protein mitochondrial, Chaperonin, 60-KD (CPN60), GROEL, HLD4, HSP65, HSPD1, HuCHA60, Mitochondrial matrix protein P1, P60 lymphocyte protein, Short heat shock protein 60 Hsp60s1, Spastic paraplegia 13 (SPG13)
Recognizes a 60kDa protein, identified as the heat shock protein 60 (hsp60). A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (hsps), more appropriately called as stress response proteins (srps). Hsp60 is a potential antigen in a number of autoimmune diseases. In human arthritis and in experimentally induced arthritis in animals, disease development coincides with the development of immune reactivity directed against not only bacterial hsp60, but also against its mammalian homolog.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Formalin-fixed, paraffin-em
Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with HSP60 Mouse Monoclonal Antibody (HSPD1/780)
Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with HSP60 Mouse Monoclonal Antibody (HSPD1/780)
Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with HSP60-Monospecific Mouse Monoclonal Antibody (HSPD1/780).
Formalin-fixed, paraffin-embedded human Pancreas stained with HSP60-Monospecific Mouse Monoclonal Antibody (HSPD1/780).
Western Blot analysis of HeLa cell lysate using HSP60-Monospecific Mouse Monoclonal Antibody (HSPD1/780)
Immunofluorescent staining of MeOH-fixed HeLa cells. HSP60-Monospecific Monoclonal Antibody (HSPD1/780) followed by goat anti-Mouse IgG-CF488 (green). Nuclei are labeled with Reddot (red).
Immunofluorescent staining of PFA-fixed MCF-7 cells. HSP60-Monospecific Monoclonal Antibody (HSPD1/780) followed by goat anti-Mouse IgG-CF488 (Green). Nuclei are labeled with Reddot (red).
Analysis of Protein Array containing more than 19,000 full-length human proteins using HSP60-Monospecific Mouse Monoclonal Antibody (HSPD1/780) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD&apos,s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD&apos,s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
SDS-PAGE Analysis of Purified HSP60 Mouse Monoclonal Antibody (HSPD1/780). Confirmation of Purity and Integrity of Antibody.
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