Recombinant IDH1-R132H (Isocitrate Dehydrogenase) Antibody, Clone: [IDH1.R132H/8205R], Rabbit, Monoclonal

Produktübersicht

• Artikelname: Recombinant IDH1-R132H (Isocitrate Dehydrogenase) Antibody, Clone: [IDH1.R132H/8205R], Rabbit, Monoclonal
• Artikelnummer: NBT-3417-RBM9-P1
• Hersteller Artikelnummer: 3417-RBM9-P1
• Alternativnummer: NBT-3417-RBM9-P1-100
• Hersteller: NeoBiotechnologies
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Recombinant fragment (around aa 1-200) of human IDH1 (exact sequence is proprietary)
• Alternative Synonym: Cytosolic NADP-isocitrate dehydrogenase, Epididymis luminal protein 216, Epididymis secretory protein Li 26, HEL-216, HEL-S-26, ICDH, IDCD, IDH1, IDP, IDPC, Isocitrate dehydrogenase 1 (NADP+) soluble, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD

Produktbeschreibung

IDH1 R132H antibody binds to IDH1-mutated protein, but does not bind the wild-type IDH1 protein. IDH1 R132H point mutations are frequently seen in World Health Organization grade II and III gliomas and are believed to constitute an early step in tumorigenesis. IDH1 R132H can be used as a diagnostic marker to help differentiate infiltrating gliomas from gliosis, and as a prognostic marker for gliomas and secondary glioblastoma multiforme. IDH1 R132H antibody shows strong cytoplasmic staining and weaker nuclear staining in tumor cells with the R132H-mutated peptide. Diffuse staining of the fibrillary tumor matrix is also seen.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [IDH1.R132H/8205R]
• Molekulargewicht: 45-47kDa
• NCBI: 3417
• UniProt: O75874
• Formulierung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.