Recombinant fragment (around aa600-920) of human AR protein (AR-V7 specific) (exact sequence is proprietary)
Alternative Synonym:
AIS, Dihydrotestosterone receptor (DHTR), HUMARA, HYSP1, Kennedy disease (KD), Nuclear receptor subfamily 3 group C member 4 (NR3C4), SMAX1, Spinal and bulbar muscular atrophy (SBMA), Testicular Feminization (TFM)
AR V7 belongs to the nuclear hormone receptor family. It contains the nuclear receptor DNA binding domain. Steroid hormone receptors are ligand-activated transcription factors that regulate the expression of eukaryotic genes affecting cell proliferation and differentiation in target tissues. The activity of transcription factors is regulated by binding co-activators and co-repressors. This target is a splice variant of the androgen receptor that lacks the C-terminal androgen-binding site. AR-V7 plays an important role in the occurrence, development and drug resistance of prostate cancer.
200ug/ml of Ab produced in HEK293 cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human prostate carcinoma stained with AR Recombinant Rabbit Monoclonal Antibody (DHTR.V7/9394R). HIER: Tris/EDTA, pH9.0, 95°,C/45min. 2°CAb: HRP-Poly:30min. DAB:5min.
SDS-PAGE Analysis of Purified AR Recombinant Rabbit Monoclonal Antibody (DHTR.V7/9394R). Confirmation of Purity and Integrity of Antibody.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
