Recombinant Cytokeratin 10 (Suprabasal Epithelial Marker) Antibody, IgG1, Clone: [MSVA-610M], Mouse, Monoclonal

Produktübersicht

• Artikelname: Recombinant Cytokeratin 10 (Suprabasal Epithelial Marker) Antibody, IgG1, Clone: [MSVA-610M], Mouse, Monoclonal
• Artikelnummer: NBT-3858-MSM18-P0
• Hersteller Artikelnummer: 3858-MSM18-P0
• Alternativnummer: NBT-3858-MSM18-P0-20
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Recombinant full-lenth human KRT10 protein.
• Alternative Synonym: BCIE, BIE, EHK, Keratin Type I Cytoskeletal 10, KRT10

Produktbeschreibung

This MAb recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation, it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [MSVA-610M]
• Molekulargewicht: 56.5kDa
• Isotyp: IgG1
• NCBI: 3858
• UniProt: P13645
• Formulierung: Ab produced in HEK293 cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide.

Bilder

Keratin, type I cytoskeletal 10 Mouse Recombinant Monoclonal Antibody (MSVA-610M) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.