MAGE-1 (Target for Cancer Immunotherapy) Antibody, IgG1, Clone: [MZ2E/838], Mouse, Monoclonal

Produktübersicht

• Artikelname: MAGE-1 (Target for Cancer Immunotherapy) Antibody, IgG1, Clone: [MZ2E/838], Mouse, Monoclonal
• Artikelnummer: NBT-4100-MSM2-P1ABX
• Hersteller Artikelnummer: 4100-MSM2-P1ABX
• Alternativnummer: NBT-4100-MSM2-P1ABX-100
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: FC, IF, IHC
• Spezies Reaktivität: Human
• Immunogen: Recombinant human MAGEA1 protein
• Alternative Synonym: MZ2 E, cancer/testis antigen 1.1, CT1.1, MAGE1A, MAGEA1, Melanoma antigen family A 1, Melanoma associated antigen 1, Melanoma associated antigen MZ2 E

Produktbeschreibung

Recognizes a protein of 42-46kDa, identified as MAGE-1. This MAb does not cross-react with other members of MAGE-family. Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [MZ2E/838]
• Molekulargewicht: 42-46kDa
• Isotyp: IgG1
• NCBI: 4100
• UniProt: P43355
• Formulierung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Antibody Type: Monoclonal Antibody

Anwendungsbeschreibung

• Anwendungsbeschreibung: Flow Cytometry (1-2ug/million cells), Immunofluorescence (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min

Bilder

Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with MAGE-1 Monoclonal Antibody (MZ2E/838).

SDS-PAGE Analysis of Purified MAGE-1 Mouse Monoclonal Antibody (MZ2E/838). Confirmation of Purity and Integrity of Antibody.