Recombinant fragment (around aa601-673) of human NR3C2 protein
Alternative Synonym:
MLR, MR
Mineralocorticoid hormones are primarily found in epithelial tissues where they function as regulators of Na+, K+ and H+ ion transport. Aldosterone is a mineralocorticoid that has been shown to regulate electrolyte excretion and intravascular volume and is therefore involved in blood pressure regulation. Mineralocorticoid receptor (MCR or MR) is a member of the steroid/thyroid/ retinoic nuclear hormone receptor superfamily that has been shown to activate gene transcription in response to aldosterone binding. Regulation of the mineralocorticoid receptors occurs through either receptor downregulation (negative autoregulation) or hormone-mediated upregulation (positive autoregulation). MCR association with HSP 90 appears to be required for hormone binding to MCR and subsequent MCR activation.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified NR3C2 Mouse Monoclonal Antibody (NR3C2/4900) Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human kidney stained with NR3C2 Mouse Monoclonal Antibody (NR3C2/4900). Inset: PBS instead of primary antibody, secondary only negative control.
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