Myelin Protein Zero / MPZ Antibody, IgG2a, Clone: [MPZ/7390], Mouse, Monoclonal
Artikelnummer:
NBT-4359-MSM2-P1ABX
Hersteller Artikelnummer:
4359-MSM2-P1ABX
Alternativnummer:
NBT-4359-MSM2-P1ABX-100
Hersteller:
NeoBiotechnologies
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human
Immunogen:
Recombinant full-length human MPZ protein
Alternative Synonym:
Charcot Marie Tooth neuropathy 1B, CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, MPZ, Myelin peripheral protein, Myelin protein P0, Myelin protein zero, MYP0_HUMAN, P0
Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified MPZ Mouse Monoclonal Antibody (MPZ/7390). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human colon stained with MPZ Mouse Monoclonal Antibody (MPZ/7390). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
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