MX1 / MX dynamin like GTPase 1 Antibody, IgG2, Clone: [MX1/7529], Mouse, Monoclonal

Produktübersicht

• Artikelname: MX1 / MX dynamin like GTPase 1 Antibody, IgG2, Clone: [MX1/7529], Mouse, Monoclonal
• Artikelnummer: NBT-4599-MSM4-P1ABX
• Hersteller Artikelnummer: 4599-MSM4-P1ABX
• Alternativnummer: NBT-4599-MSM4-P1ABX-100
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Recombinant fragment (around aa400-592) of human MX1 protein (exact sequence is proprietary)
• Alternative Synonym: Human interferon regulated resistance GTP binding protein MXA, IFI78K, Interferon induced GTP binding protein Mx1, Interferon inducible protein p78, Interferon regulated resistance GTP binding protein MxA, MxA, Myxoma resistance protein 1, Myxovirus (influenza virus) resistance 1 interferon inducible, N-terminally processed

Produktbeschreibung

The Dynamin family of microtubule-associated proteins function as GTPases that are involved in microtubule bundling and endocytosis. In mice, Mx2 (myxovirus resistance protein 2) and Mx1 (myxovirus resistance protein 1) are members of the Dynamin family that are involved in the immune response to viral infections. Localized to the cytoplasm, Mx2 contains one GED domain and is expressed in response to viral infection or treatment by IFN-a/IFN-b. Once expression is induced, Mx2 accumulates in the cytoplasm and inhibits the replication of vesicular stomatitis virus (VSV), thereby conferring resistance to VSV infection. Unlike Mx2, Mx1 is localized to the nucleus where, upon induction by IFN-a/IFN-b, it provides selective resistance to infection by the highly lethal H5N1 influenza virus. In humans, MxA and MxB function in a similar manner to Mx1 and Mx2, conferring resistance to specific target viruses. Mx3 is a rat-specific member of the myxovirus resistance protein family.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [MX1/7529]
• Molekulargewicht: 72kDa
• Isotyp: IgG2
• NCBI: 4599
• UniProt: P20591
• Formulierung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Bilder

SDS-PAGE Analysis Purified MX1 Mouse Monoclonal Antibody (MX1/7529). Confirmation of Purity and Integrity of Antibody.

IHC analysis of formalin-fixed, paraffin-embedded human ovarian cancer. MX1 Mouse Monoclonal Antibody (MX1/7529). Inset: PBS instead of primary antibody, secondary only negative control.

IHC analysis of formalin-fixed, paraffin-embedded human kidney. MX1 Mouse Monoclonal Antibody (MX1/7529). Inset: PBS instead of primary antibody, secondary only negative control.