CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody, IgG1, Clone: [NCAM1/6715], Mouse, Monoclonal

Produktübersicht

• Artikelname: CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody, IgG1, Clone: [NCAM1/6715], Mouse, Monoclonal
• Artikelnummer: NBT-4684-MSM18-P1ABX
• Hersteller Artikelnummer: 4684-MSM18-P1ABX
• Alternativnummer: NBT-4684-MSM18-P1ABX-100
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Recombinant fragment (around aa400-650) of human NCAM1 protein (exact sequence is proprietary)
• Alternative Synonym: NCAM, Leu-19, NKH1, MSK39, NCAM120, NCAM140, NCAM180, Neural Cell Adhesion Molecule

Produktbeschreibung

This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [NCAM1/6715]
• Molekulargewicht: 180, 145 and 125kDa
• Isotyp: IgG1
• NCBI: 4684
• UniProt: P13591
• Formulierung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Bilder

Formalin-fixed, paraffin-embedded human ovarian cancer stained with CD56 Mouse Monoclonal Antibody (NCAM1/6715). Inset: PBS instead of primary antibody, secondary only negative control.