Recombinant fragment (around aa1-200) of human PDGFRA protein (exact sequence is proprietary)
Alternative Synonym:
Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, PDGFR 2, PDGFRA/BCR fusion, Platelet derived growth factor receptor 2, Platelet derived growth factor receptor alpha polypeptide, Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein, RHEPDGFRA
Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-a and -, which are endowed with protein tyrosine kinase domains. PDGFR-a can bind to both A and B subunits of PDGF, while PDGFR- can only bind the B subunit. Ligand binding promotes either homo- or heterodimerization of the PDGF receptors in a specific manner. PDGF-AA induces the dimerization of two a receptors, PDGF-AB induces dimerization of aa and a and PDGF-BB induces the formation of three types of dimers, aa, a and . Translocation of the PDGFR- gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified PDGFR-A Mouse Monoclonal Antibody (PDGFRA/7407). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human colon cancer stained with PDGFR-A Mouse Monoclonal Antibody (PDGFRA/7407). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
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