Bcl-6, a transcriptional repressor, can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin,Aos lymphoma. BCoR (Bcl-6 corepressor) is a 1,755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression, BCoR is localized to the nucleus where it interacts with other proteins through its three ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2, also known as anophthalmia, which is characterized by variable features, such as renal aplasia, mental retardation, hyospadias, microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified BCOR Recombinant Rabbit Monoclonal Antibody (BCOR/13087R). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of human brain tissue lysate using BCOR Recombinant Rabbit Monoclonal Antibody (BCOR/13087R).
54880-RBM5-P1ABX
Formalin-fixed, paraffin-embedded human tonsil stained with BCOR Recombinant Rabbit Monoclonal Antibody (BCOR/13087R). Inset: PBS instead of primary antibody, secondary only negative control.
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