Recombinant DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Antibody, IgG2b, Clone: [MSVA-201M], Mouse, Monoclonal

Produktübersicht

• Artikelname: Recombinant DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Antibody, IgG2b, Clone: [MSVA-201M], Mouse, Monoclonal
• Artikelnummer: NBT-55107-MSM16-P1
• Hersteller Artikelnummer: 55107-MSM16-P1
• Alternativnummer: NBT-55107-MSM16-P1-100
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Recombinant full-length human DOG-1 protein
• Alternative Synonym: Anoctamin 1, Calcium Activated Chloride Channel, Discovered On Gastrointestinal Stromal Tumors Protein 1, TAOS2, ORAOV2, TMEM16A

Produktbeschreibung

Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [MSVA-201M]
• Molekulargewicht: ~114kDa
• Isotyp: IgG2b
• NCBI: 55107
• UniProt: Q5XXA6
• Formulierung: Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide.

Bilder

Anoctamin-1 Mouse Monoclonal Antibody (MSVA-201M) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.