Calcineurin B / PPP3R1 Antibody, IgG1, Clone: [CALNB/2342], Mouse, Monoclonal
Artikelnummer:
NBT-5534-MSM2-P1ABX
Hersteller Artikelnummer:
5534-MSM2-P1ABX
Alternativnummer:
NBT-5534-MSM2-P1ABX-100
Hersteller:
NeoBiotechnologies
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human
Immunogen:
Recombinant full-length Calcineurin B protein
Alternative Synonym:
Calcineurin B, type I (19kDa), Calcineurin subunit B type 1, CALNB1, CNB1, PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform, Protein phosphatase 3 regulatory subunit B alpha, Protein phosphatase 3 regulatory subunit B alpha isoform 1
Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Anwendungsbeschreibung:
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes), Optimal dilution for a
Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Calcineurin B Mouse Monoclonal Antibody (CALNB/2342).
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
