Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody, IgG2b, Clone: [B2M/961], Mouse, Monoclonal

Produktübersicht

• Artikelname: Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody, IgG2b, Clone: [B2M/961], Mouse, Monoclonal
• Artikelnummer: NBT-567-MSM5-P1
• Hersteller Artikelnummer: 567-MSM5-P1
• Alternativnummer: NBT-567-MSM5-P1-100
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: FC, IF, IHC, WB
• Spezies Reaktivität: Human, Primate
• Immunogen: Full length recombinant human B2M protein
• Alternative Synonym: B2M, Beta 2 microglobin, Beta 2 microglobulin, Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, Hdcma22p

Produktbeschreibung

Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [B2M/961]
• Molekulargewicht: 12kDa
• Isotyp: IgG2b
• NCBI: 567
• UniProt: P61769
• Formulierung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Bilder

Formalin-fixed, paraffin-embedded human cervical carcinoma stained with Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961).

SDS-PAGE Analysis Purified Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961). Confirmation of Integrity and Purity of Antibody.

Western Blot Analysis of THP-1 and Raji cell lysates using Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961).

Immunofluorescence Analysis of HeLa cells labeling with Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961) followed by goat anti-mouse IgG-CF488 (green). nuclei stained with RedDot (red).

Flow Cytometric Analysis of human HeLa cells. Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961) followed by goat anti-mouse IgG-CF488 (blue), isotype control (red).

Formalin-fixed, paraffin-embedded human melanoma stained with Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961).

Formalin-fixed, paraffin-embedded human endometrial carcinoma stained with Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961).

Formalin-fixed, paraffin-embedded human gastric carcinoma stained with Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961).

Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961).

Formalin-fixed, paraffin-embedded human cervical carcinoma stained with Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961).

Formalin-fixed, paraffin-embedded human bladder carcinoma stained with Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961).

Formalin-fixed, paraffin-embedded human colon carcinoma stained with Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961).

Formalin-fixed, paraffin-embedded human cervical carcinoma stained with Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/961).