Recombinant Bcl-6 (Follicular Lymphoma Marker) Antibody, IgG1, Clone: [rBCL6/1718], Mouse, Monoclonal

Produktübersicht

• Artikelname: Recombinant Bcl-6 (Follicular Lymphoma Marker) Antibody, IgG1, Clone: [rBCL6/1718], Mouse, Monoclonal
• Artikelnummer: NBT-604-MSM14-P1ABX
• Hersteller Artikelnummer: 604-MSM14-P1ABX
• Alternativnummer: NBT-604-MSM14-P1ABX-100
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Recombinant human bcl-6 protein fragment (aa256-389) (exact sequence is proprietary)
• Alternative Synonym: B-cell lymphoma 5 protein, B-Cell Lymphoma 6 Protein, BCL5, BCL6, BCL6A, cys his2 zinc finger transcription factor, Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3), Zinc finger and BTB domain-containing protein 27 (ZBTB27), Zinc Finger Protein 51 (ZNF51), zinc finger transcription factor BCL6S

Produktbeschreibung

Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (LH) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [rBCL6/1718]
• Molekulargewicht: 95kDa
• Isotyp: IgG1
• NCBI: 604
• UniProt: P41182
• Formulierung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Antibody Type: Recombinant Monoclonal Antibody

Anwendungsbeschreibung

• Anwendungsbeschreibung: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)Optimal dilution

Bilder

Formalin-fixed, paraffin-embedded human Tonsil stained with BCL-6 Mouse Recombinant Monoclonal Antibody (rBCL6/1718).

SDS-PAGE Analysis of Purified BCL-6 Mouse Recombinant Monoclonal Antibody (rBCL6/1718). Confirmation of Integrity and Purity of Antibody.