Recombinant Bcl-6 (Follicular Lymphoma Marker) Antibody, Clone: [BCL6/8983R], Rabbit, Monoclonal

Produktübersicht

• Artikelname: Recombinant Bcl-6 (Follicular Lymphoma Marker) Antibody, Clone: [BCL6/8983R], Rabbit, Monoclonal
• Artikelnummer: NBT-604-RBM30-P0
• Hersteller Artikelnummer: 604-RBM30-P0
• Alternativnummer: NBT-604-RBM30-P0-20
• Hersteller: NeoBiotechnologies
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IHC, WB
• Spezies Reaktivität: Human
• Immunogen: Recombinant fragment (aa1-400) of human BCL6 protein (exact sequence is proprietary)
• Alternative Synonym: B-cell lymphoma 5 protein, B-Cell Lymphoma 6 Protein, BCL5, BCL6, BCL6A, cys his2 zinc finger transcription factor, Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3), Zinc finger and BTB domain-containing protein 27 (ZBTB27), Zinc Finger Protein 51 (ZNF51), zinc finger transcription factor BCL6S

Produktbeschreibung

Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( L&H ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [BCL6/8983R]
• Molekulargewicht: 95kDa
• NCBI: 604
• UniProt: P41182
• Formulierung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Bilder

SDS-PAGE Analysis of Purified bcl-6 Recombinant Rabbit Monoclonal Antibody (BCL6/8983R). Confirmation of Purity and Integrity of Antibody.

Western Blot Analysis of Raji and Ramos lysates using BCL6 Recombinant Rabbit Monoclonal Antibody (BCL6/8983R).

Formalin-fixed, paraffin-embedded human tonsil stained with BCL-6 Rabbit Recombinant Monoclonal Antibody (BCL6/8983R). Inset: PBS instead of primary antibody, secondary only negative control.