GST-tagged recombinant protein corresponding to human Gamma-parvin
Alternative Synonym:
Gamma parvin, PARVG
The parvin family, including (TM)-parvin, A°a-parvin and A-parvin, link integrins and associated proteins with intracellular pathways, which regulate actin cytoskeletal dynamics and cell survival. All three family members localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK), paxillin, (TM)-actinin and testicular kinase 1. (TM)-parvin is widely expressed, with highest levels detected in the skeletal muscle, heart, liver and kidney. A complex made up of (TM)-parvin, ILK and the LIM protein PINCH-1 is critical for cell survival in a variety of cells, including certain cancer cells, kidney podocytes and cardiac myocytes. A°a-parvin links initial integrin signals to rapid actin reorganization, thereby playing a critical role in fibroblast migration. The ILK-A-parvin complex is essential for the establishment of cell polarity required for leukocyte migration.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Anwendungsbeschreibung:
Immunoprecipitation (1-2ug per 100-500ug of total protein (1ml of cell lysate)), Western Blot (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM T
SDS-PAGE Analysis of Purified Gamma parvin Mouse Monoclonal Antib
Formalin-fixed, paraffin-embedded human tonsil stained with Gamma parvin Mouse Monoclonal Antibody (8C5.2) at 2ug/ml in PBS. Inset: PBS instead of primary, secondary only antibody control.
SDS-PAGE Analysis of Purified Gamma parvin Mouse Monoclonal Antibody (8C5.2). Confirmation of Purity and Integrity of Antibody.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
