Prokaryotic recombinant protein corresponding to a portion of the C-terminus of the human osteonectin molecule
Alternative Synonym:
Basement membrane protein 40, BM40, Cysteine rich protein, OI17, ON, Osteonectin, Secreted acidic cystein rich glycoprotein, Secreted protein acidic and cysteine rich, Secreted protein acidic and rich in cysteine (SPARC)
Osteonectin (ON), also known as BM-40 or SPARC (secreted protein, acidic and rich in cysteine) is a multifunctional glycoprotein (32.5 kD) involved with tissue mineralization as well as extracellular matrix modelling. It is the most abundant glycoprotein secreted by human osteoblasts in developing bone and odontoblasts of developing teeth. ON mRNA and protein have been detected in non-mineralized tissues such as steroid-producing cells of the adrenal glands, suprabasal layers of the epidermis, glomeruli in the kidney, bronchi of the lung, megakaryocytes and large vessels. This organ-specific distribution in non-mineralized tissues suggests a role during human development.
200ug/ml of Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Western blot analysis of A-375 cell lysate using SPARC / Osteonectin Recombinant Mouse Monoclonal Antibody (r15G12).
Formalin-fixed, paraffin-embedded human testis stained with SPARC / Osteonectin Recombinant Mouse Monoclonal Antibody (r15G12). Inset: PBS instead of primary antibody, secondary only negative control.
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