pS2 / pNR-2 / TFF1 (Estrogen-Regulated Protein) Antibody, IgG1, Clone: [GE2, same as R47/94], Mouse, Monoclonal
Artikelnummer:
NBT-7031-MSM1-P1ABX
Hersteller Artikelnummer:
7031-MSM1-P1ABX
Alternativnummer:
NBT-7031-MSM1-P1ABX-100
Hersteller:
NeoBiotechnologies
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human, Primate
Immunogen:
A synthetic peptide (around aa 57-84) of human pS2/TFF1 polypeptide (exact sequence is proprietary)
Alternative Synonym:
BCEI, Breast Cancer Estrogen Inducible Protein, Gastrointestinal Trefoil Protein, Gastrointestinal trefoil protein pS2, HP1A, HPS2, pNR2, TFF1, Trefoil Factor 1
It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Anwendungsbeschreibung:
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes), Optimal dilution f
SDS-PAGE Analysis of Purified pS2 Mouse
Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with pS2 Mouse Monoclonal Antibody (GE2).
Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with pS2 Mouse Monoclonal Antibody (GE2).
SDS-PAGE Analysis of Purified pS2 Mouse Monoclonal Antibody (GE2). Confirmation of Purity and Integrity of Antibody.
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