Recombinant pS2 / pNR-2 / TFF1 (Estrogen-Regulated Protein) Antibody, Clone: [TFF1/2969R], Rabbit, Monoclonal

Produktübersicht

• Artikelname: Recombinant pS2 / pNR-2 / TFF1 (Estrogen-Regulated Protein) Antibody, Clone: [TFF1/2969R], Rabbit, Monoclonal
• Artikelnummer: NBT-7031-RBM4-P0
• Hersteller Artikelnummer: 7031-RBM4-P0
• Alternativnummer: NBT-7031-RBM4-P0-20,NBT-7031-RBM4-P0-100
• Hersteller: NeoBiotechnologies
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IHC, WB
• Spezies Reaktivität: Human, Primate
• Immunogen: Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-terminus of human pS2
• Alternative Synonym: BCEI, Breast Cancer Estrogen Inducible Protein, Gastrointestinal Trefoil Protein, Gastrointestinal trefoil protein pS2, HP1A, HPS2, pNR2, TFF1, Trefoil Factor 1

Produktbeschreibung

It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [TFF1/2969R]
• Molekulargewicht: 6.5kDa
• NCBI: 7031
• UniProt: P04155
• Formulierung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Antibody Type: Recombinant Monoclonal Antibody

Anwendungsbeschreibung

• Anwendungsbeschreibung: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes), Optimal dilution f

Bilder

Formalin-fixed, paraffin-embedded human Stomach Carcinoma stained with pS2 Rabbit Recombinant Monoclonal Antibody (TFF1/2969R).

SDS-PAGE Analysis of Purified pS2 Rabbit Recombinant Monoclonal Antibody (TFF1/2969R). Confirmation of Purity and Integrity of Antibody.

Western Blot Analysis of Human Stomach tissue lysate using TFF1 Recombinant Rabbit Monoclonal Antibody (TFF1/2969R).

Western Blot Analysis of Human Stomach, Mouse Stomach, Rat Stomach, Hamster Stomach, Guinea pig Stomach and Rabbit Stomach tissue lysates using TFF1 Recombinant Rabbit Monoclonal Antibody (TFF1/2969R).