This MAb recognizes TGF beta 1, 2 and 3. Three TGFs have been identified in mammals. TGF1, TGF2 and TGF3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF3 protein has approximately 80% identity to the mature region of both TGF1 and TGF2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGF s inhibits the growth of epithelial cells and stimulate the growth of mesenchymal cells. OO
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified TGF beta Mouse Monoclonal Antibody (TGFB/7240). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human placenta stained with TGF beta Mouse Monoclonal Antibody (TGFB/7240). Inset: PBS instead of primary antibody, secondary only negative control.
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