Recombinant fragment (around aa 241-356) of human TNFAIP3 protein (exact sequence is proprietary)
Alternative Synonym:
A20, Putative DNA-binding protein A20, TNF alpha-induced protein 3 (TNFAIP3), Tumor Necrosis Factor alpha-Induced Protein 3(TNFAIP3), Zinc finger protein A20
A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. HighA20expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human hepatocellular carcinoma stained with TNFAIP3 Mouse Monoclonal Antibody (TNFAIP3/2813).
Formalin-fixed, paraffin-embedded human breast carcinoma stained with TNFAIP3 Mouse Monoclonal Antibody (TNFAIP3/2813).
SDS-PAGE Analysis of Purified A20 / TNFAIP3 Mouse Monoclonal Antibody (TNFAIP3/2813). Confirmation of Purity and Integrity of Antibody.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
