TRPC6 / Transient Receptor Potential Cation Channel Subfamily C Member 6 Antibody, IgG2, Clone: [TRPC6/7671], Mouse, Monoclonal

Produktübersicht

• Artikelname: TRPC6 / Transient Receptor Potential Cation Channel Subfamily C Member 6 Antibody, IgG2, Clone: [TRPC6/7671], Mouse, Monoclonal
• Artikelnummer: NBT-7225-MSM1-P0
• Hersteller Artikelnummer: 7225-MSM1-P0
• Alternativnummer: NBT-7225-MSM1-P0-20
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Recombinant full-length human TRPC6 protein
• Alternative Synonym: bZ1P14.9, FLJ11098, FLJ14863, FSGS2, MTRP6, Short transient receptor potential channel 6, si:rp71-1p14.9, Transient receptor potential cation channel subfamily C member 6, Transient receptor protein 6, TRRP6

Produktbeschreibung

Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate, and is likely to be involved in the formation of the hydroxylating intermediate. TPH is both the first and rate-limiting-step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, LDOPA, which is used as a common therapy for Parkinson s disease (PD) patients, inhibits TPH function which, subsequently, is thought to contribute to the onset of depression in PD patients.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [TRPC6/7671]
• Molekulargewicht: 50.9kDa
• Isotyp: IgG2
• NCBI: 7225
• UniProt: Q9Y210
• Formulierung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Bilder

SDS-PAGE Analysis of Purified TRPC6 Mouse Monoclonal Antibody (TRPC6/7671). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human pancreas stained with TRPC6 Mouse Monoclonal Antibody (TRPC6/7671). Inset: PBS instead of primary antibody, secondary only negative control.