This MAb recognizes proteins of 19-22kDa (reducing) and 38kDa-44kDa (non-reducing), identified as various isoforms of Vascular Endothelial Growth Factor or Vascular Permeability Factor (VEGF/VPF). It is highly specific to VEGF, which is a homodimeric, disulfide-linked glycoprotein with a close homology to platelet derived growth factor (PDGF). There are multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[VEGF/1063]
Molekulargewicht:
19-22kDa (reducing) and 38kDa-44kDa (non-reducing)
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Anwendungsbeschreibung:
Immunofluorescence (1-2ug/ml), ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT
SDS-PAGE Analysis Purified VEGF Mou
Formalin-fixed, paraffin-embedded human tonsil stained with VEGF Mouse Monoclonal Antibody (VEGF/1063).
Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with VEGF Mouse Monoclonal Antibody (VEGF/1063).
SDS-PAGE Analysis Purified VEGF Mouse Monoclonal Antibody (VEGF/1063). Confirmation of Purity and Integrity of Antibody.
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