Recombinant fragment (around aa300-500) of human XRCC5 (exact sequence is proprietary)
Alternative Synonym:
ATP-dependent DNA helicase II 80kDa subunit, CTC box-binding factor 85kDa subunit (CTC85), CTCBF, DNA repair protein XRCC5, KARP1, Ku autoantigen 80kDa, Ku80, Ku86, KUB2, Lupus Ku autoantigen protein p86, Nuclear factor IV (NFIV), Thyroid-lupus autoantigen, TLAA, X-ray repair cross-complementing protein 5 (XRCC5)
The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Ku has several functions, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters.
Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide.
X-ray repair cross-complementing protein 5 Mouse Monoclonal Antibody (MSVA-880M) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.
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