Recombinant fragment (around aa300-500) of human XRCC5 (exact sequence is proprietary)
Alternative Synonym:
ATP-dependent DNA helicase II 80kDa subunit, CTC box-binding factor 85kDa subunit (CTC85), CTCBF, DNA repair protein XRCC5, KARP1, Ku autoantigen 80kDa, Ku80, Ku86, KUB2, Lupus Ku autoantigen protein p86, Nuclear factor IV (NFIV), Thyroid-lupus autoantigen, TLAA, X-ray repair cross-complementing protein 5 (XRCC5)
The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Ku has several functions, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified XRCC5 / Ku86 / Ku80 Mouse Monoclonal Antibody (XRCC5/7312). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human lymph node stained with XRCC5 / Ku86 / Ku80 Mouse Monoclonal Antibody (XRCC5/7312). Inset: PBS instead of primary antibody, secondary only negative control.
Formalin-fixed, paraffin-embedded human skin stained with XRCC5 / Ku86 / Ku80 Mouse Monoclonal Antibody (XRCC5/7312). Inset: PBS instead of primary antibody, secondary only negative control.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
