Homologous to the poliovirus receptor (PVR/CD155), the nectin immunoglobulin superfamily comprises four known isoforms (-1, -2, -3, and -4). The ectodomain of nectin family members comprises three Ig-like domains (V, C, C). Nectins localize at the adherens junctions (AJ) in epithelial and endothelial cells where they serve as adhesion molecules. Actin-based AJs play a role in mechanical adhesion, cellular morphogenesis and cellular differentiation. Nectin associates with the actin cytoskeleton through its interaction with the actin filament-binding protein afadin. Nectin 4 and afadin co-localize at cadherin-based adherens junctions in MDCKII epithelial cells. Nectin 4 and nectin 3 share a common binding region in the V domain of Nectin 1 and thus compete for Nectin 1 binding. The Nectin 3/4 binding domain maps to the C-C-C-D A°a strands of the V domain of Nectin 1. Unlike other nectins, which are more widely expressed, Nectin 4 is mainly expressed in the placenta.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Western Blot Analysis of U87 cell lysate using NTRK2 Mouse Monoclonal Antibody (NTRK2/4672).
Western blot analysis of human brain and U87 lysates using NTRK2 Mouse Monoclonal Antibody (NTRK2/7925).
Western Blot Analysis of human brain and U87 lysates using NTRK2 Mouse Monoclonal Antibody (NTRK2/7928).
Western Blot Analysis of U-87 cell lysate using NTRK3 Mouse Monoclonal Antibody (NTRK3/8796).
SDS-PAGE Analysis of Purified Nectin 4 Mouse Monoclonal Antibody (NECTIN4/9906). Confirmation of Purity and Integrity of Antibody.
Western blot analysis of A-431 and MCF7 cell lysates using NECTIN 4 Mouse Monoclonal Antibody (NECTIN4/9906).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Nectin 4 Mouse Monoclonal Antibody (NECTIN4/9906). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD&apos,s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD&apos,s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Formalin-fixed, paraffin-embedded human placenta stained with Nectin 4 Mouse Monoclonal Antibody (NECTIN4/9906). Inset: PBS instead of primary antibody, secondary only negative control.
Formalin-fixed, paraffin-embedded human skin stained with Nectin 4 Mouse Monoclonal Antibody (NECTIN4/9906). Inset: PBS instead of primary antibody, secondary only negative control.
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