Recombinant fragment (around aa500-697) of human SIGLEC10 protein (exact sequence is proprietary)
Alternative Synonym:
mSiglec G, PRO940, sialic acid binding Ig like lectin 10 Ig like lectin 7, Sialic acid binding Immunoglobulin like lectin 10, Siglec G, siglec like gene 2, Siglec like protein 2, Siglecg, SLG2
Siglec-10 (sialic acid-binding Ig-like lectin 10) is a 697 amino acid protein belonging to the immunoglobulin superfamily. The N-terminal Ig-like domain of Siglec-10 contains a sialic acid-binding site and the C-terminal cytoplasmic region of Siglec-10 contains two immunoreceptor tyrosine-based inhibitor motifs (ITIMs), which are involved in the modulation of cellular responses through SH2 domains. With most expression in spleen, bone marrow and peripheral blood lymphocytes, such as monocytes, natural killer cells and eosinophils, it is likely that Siglec-10 functions as an inhibitory receptor in the immune response. Importantly, Siglec-10 mRNA is found to be highly upregulated in eosinophils at sites of inflammation in asthmatics, suggesting that Siglec-10 may be an appropriate target for new approaches of immunomodulatory therapy. There are six named isoforms of Siglec-10 that are a result of alternative splicing. All isoforms exists as single-pass transmembrane proteins, except for isoform 6, which is secreted.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified SIGLEC10 Mouse Monoclonal Antibody (SIGLEC10/7582). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human small intestine stained with SIGLEC10 Mouse Monoclonal Antibody (SIGLEC10/7582). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
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