CD6 (Negative Marker of T-regulatory Cells) Antibody, IgG1, Clone: [C6/372+3F7B5], Mouse, Monoclonal

Produktübersicht

• Artikelname: CD6 (Negative Marker of T-regulatory Cells) Antibody, IgG1, Clone: [C6/372+3F7B5], Mouse, Monoclonal
• Artikelnummer: NBT-923-MSM4-P1
• Hersteller Artikelnummer: 923-MSM4-P1
• Alternativnummer: NBT-923-MSM4-P1-100
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: IF, IHC
• Spezies Reaktivität: Human
• Immunogen: Human recombinant CD6 protein (C6/372), Human rheumatoid synovial T cell line ST-1 (3F7B5)
• Alternative Synonym: T12, TP120

Produktbeschreibung

CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [C6/372+3F7B5]
• Molekulargewicht: 90-130kDa
• Isotyp: IgG1
• NCBI: 923
• UniProt: P30203
• Formulierung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Bilder

Formalin-fixed, paraffin-embedded human Tonsil stained with CD6 Monoclonal Antibody (C6/372+3F7B5).

Formalin-fixed, paraffin-embedded human Tonsil stained with CD6 Monoclonal Antibody (C6/372+3F7B5).

Immunofluorescence staining of MOLT-4 cells using CD6 Monoclonal Antibody (C6/372+3F7B5) followed by goat anti-Mouse IgG conjugated to CF488 (green). Nuclei are stained with Reddot.