Prokaryotic recombinant fusion protein corresponding to the entire external domain of the CD40 molecule
Alternative Synonym:
TNFRSF5
The CD40 antigen is a single chain glycoprotein with a calculated molecular weight of 27 kD. It is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin,Aos disease-associated antigen, CD30. The precise function of the CD40 antigen is unknown, but it appears to be involved in the transduction of regulatory signals for cellular functions such as B cell proliferation and differentiation. It is also important in the prevention of apoptosis of germinal centre B cells. The CD40 antigen is found on mature B cells (except plasma cells), interdigitating reticulum cells and follicular dendritic cells.
200ug/ml of Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified CD40 Recombinant Mouse Monoclonal Antibody (r11E9). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human tonsil stained with CD40 Recombinant Mouse Monoclonal Antibody (r11E9). Inset: PBS instead of primary antibody, secondary only negative control.
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