cAMP response element-binding protein CREBPa (CRE-BPa), cAMP responsive element binding protein 5 isoform alpha, CRE BPA, CREBPA, cyclic AMP responsive element binding protein 5
The ATF/CREB family consists of a series of transcription factors that function by binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2 (also designated ATF-4), CRE-BPa, LZIP (also designated CREB-3 and Luman), CREM-2, ATF-1, ATF-2, ATF-3, ATF-5, ATF-6 and ATF-7. These transcription factors share terminal leucine zipper dimerization and basic DNA binding domains and are highly variable in their N-termini. Although each of the ATF/ CREB proteins bind CREs in their homodimeric form, they can also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. Protein kinase A- mediated CREB phosphorylation induces association with a nuclear protein designated CBP (CREB-binding protein), which may represent a CREB coactivator. CRE-BPa is a nuclear protein that binds DNA as a homodimer but can also form a heterodimer with ATF-2 or Jun.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Immunofluorescent analysis of PFA-fixed K562 cells stained with CREB5 Mouse Monoclonal
Flow cytometric analysis of PFA-fixed HeLa cells. CREB5 Mouse Monoclonal Antibody (PCRP-CREB5-1G8) followed by goat anti-mouse IgG-CF488 (blue), unstained cells (red).
Immunofluorescent analysis of PFA-fixed K562 cells stained with CREB5 Mouse Monoclonal Antibody (PCRP-CREB5-1G8) followed by goat anti-mouse IgG-CF488 (green), phalloidin counterstain (red).
Flow cytometric analysis of PFA-fixed K562 cells. CREB5 Mouse Monoclonal Antibody (PCRP-CREB5-1G8) followed by goat anti-mouse IgG-CF488 (blue), unstained cells (red).
Western blot analysis of HeLa cell lysate using CREB5 Mouse Monoclonal Antibody (PCRP-CREB5-1G8).
Analysis of Protein Array containing more than 19,000 full-length human proteins using CREB5 Mouse Monoclonal Antibody (PCRP-CREB5-1G8). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD&apos,s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD&apos,s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
SDS-PAGE Analysis. Purified CREB5 Mouse Monoclonal Antibody (PCRP-CREB5-1G8). Confirmation of Purity and Integrity of Antibody.
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