Puma Antibody, Rabbit, Polyclonal

Produktübersicht

• Artikelname: Puma Antibody, Rabbit, Polyclonal
• Artikelnummer: NSJ-F42785-0.4ML
• Hersteller Artikelnummer: F42785-0.4ML
• Alternativnummer: NSJ-F42785-0.4ML
• Hersteller: NSJ Bioreagents
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, FACS, IF, IHC, WB
• Spezies Reaktivität: Human
• Immunogen: A portion of amino acids 119-154 (BH3 domain) from the alpha isoform was used as the immunogen for this Puma antibody.

Produktbeschreibung

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Produkteigenschaften

• Klonalität: Polyclonal
• UniProt: Q9BXH1
• Reinheit: Purified
• Formulierung: In 1X PBS, pH 7.4, with 0.09% sodium azide
• Antibody Type: Primary Antibody

Anwendungsbeschreibung

• Application Verdünnung: Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50
• Anwendungsbeschreibung: Titration of the Puma antibody may be required due to differences in protocols and secondary/substrate sensitivity.