SMAD3 Antibody, Rabbit, Polyclonal

Produktübersicht

• Artikelname: SMAD3 Antibody, Rabbit, Polyclonal
• Artikelnummer: NSJ-F43048-0.08ML
• Hersteller Artikelnummer: F43048-0.08ML
• Alternativnummer: NSJ-F43048-0.08ML
• Hersteller: NSJ Bioreagents
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, IF, IHC, WB
• Spezies Reaktivität: Human
• Immunogen: A portion of amino acids 127-156 from the human protein was used as the immunogen for this SMAD3 antibody.

Produktbeschreibung

SMAD3 is a receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF- mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [UniProt]

Produkteigenschaften

• Klonalität: Polyclonal
• UniProt: P84022
• Reinheit: Antigen affinity
• Formulierung: In 1X PBS, pH 7.4, with 0.09% sodium azide
• Antibody Type: Primary Antibody

Anwendungsbeschreibung

• Application Verdünnung: Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:10-1:50
• Anwendungsbeschreibung: Titration of the SMAD3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.