A portion of amino acids 84-111 from the mouse protein was used as the immunogen for this Aurkb antibody.
Aurkb may be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Phosphorylates Ser-10 and Ser-28 of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1 (By similarity).
