A portion of amino acids 608-641 from human DLL4 was used as the immunogen for the DLL4 antibody.
Delta-like protein 4 is involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. [UniProt]
The stated application concentrations are suggested starting points. Titration of the DLL4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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