Recombinant human DKK2 was used as the immunogen for the DKK2 antibody.
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). [UniProt]
The stated application concentrations are suggested starting points. Titration of the DKK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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