A portion of amino acids 362-390 from the human protein were used as the immunogen for the PCCA antibody.
The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.
Western blot: 1:1000-1:2000,Immunohistochemistry (FFPE): 1:25
Anwendungsbeschreibung:
The stated application concentrations are suggested starting points. Titration of the PCCA antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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