FAM50A Antibody / Family with sequence similarity 50 member A, Clone: [30F36], Rabbit, Monoclonal
Artikelnummer:
NSJ-FY12219
Hersteller Artikelnummer:
FY12219
Alternativnummer:
NSJ-FY12219
Hersteller:
NSJ Bioreagents
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ICC, IF, IHC, WB
Spezies Reaktivität:
Human, Mouse, Rat
Immunogen:
A synthesized peptide derived from human FAM50A was used as the immunogen for the FAM50A antibody.
FAM50A antibody detects family with sequence similarity 50 member A, a nuclear protein involved in RNA processing and gene expression regulation. FAM50A is ubiquitously expressed and localized primarily to the nucleoplasm, where it associates with spliceosomal components and contributes to pre-mRNA splicing. Though relatively understudied compared to other RNA-binding proteins, evidence suggests FAM50A plays an important role in transcriptional control and cellular homeostasis.Research using FAM50A antibody has linked the protein to development and disease. Genetic studies reveal that mutations in FAM50A cause Armfield X-linked intellectual disability syndrome, characterized by developmental delay, dysmorphic features, and neurobehavioral abnormalities. The disorder underscores FAM50As significance in neurodevelopment and proper RNA processing. Knockout models further demonstrate embryonic lethality or severe neurological phenotypes, confirming its essential role.Beyond development, FAM50A has been implicated in cancer biology. Altered expression is observed in several tumor types, where it may influence splicing decisions and transcriptional programs that favor proliferation. Transcriptome studies suggest that dysregulation of FAM50A perturbs global RNA processing networks, contributing to oncogenic transformation.At the molecular level, FAM50A interacts with spliceosome-associated proteins, ribonucleoprotein complexes, and chromatin regulators. These interactions suggest a broader role in coupling transcription to RNA maturation. Additional evidence connects FAM50A to cell cycle control, where depletion disrupts proliferation and induces apoptosis.Antibodies against FAM50A are validated for western blot, immunohistochemistry, and immunofluorescence. These reagents enable detection of FAM50A in tissue and cell culture, supporting research into RNA biology, neurodevelopment, and tumorigenesis. Clone-based antibodies ensure reproducibility and specificity across experimental conditions.NSJ Bioreagents offers this FAM50A antibody for research into RNA processing, gene regulation, and disease.
