Zebrafish ATP binding cassette E1 Antibody / Abce1, Rabbit, Polyclonal
Artikelnummer:
NSJ-RZ1144
Hersteller Artikelnummer:
RZ1144
Alternativnummer:
NSJ-RZ1144
Hersteller:
NSJ Bioreagents
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC-P, WB
Spezies Reaktivität:
Zebrafish
Immunogen:
An E.coli-derived zebrafish ABCE1 recombinant protein (amino acids Q141-D599) was used as the immunogen for the Zebrafish ATP binding cassette E1 antibody.
ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5-phosphorylated 2,5-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumorcell proliferation and antiapoptosis.
