Coagulation Factor VII Antibody / F7, Clone: [F7/3512], Mouse, Monoclonal
Artikelnummer:
NSJ-V4329-20UG
Hersteller Artikelnummer:
V4329-20UG
Alternativnummer:
NSJ-V4329-20UG
Hersteller:
NSJ Bioreagents
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
ELISA, IHC-P
Spezies Reaktivität:
Human
Immunogen:
A recombinant partial protein sequence (within amino acids 366-466) from the human protein was used as the immunogen for the Coagulation Factor VII antibody.
Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IX A, Factor X A, Factor XII A or Thrombin-mediated proteolytic cleavage of Factor VII at Arg 152-Ile 153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels.
