Polo like kinase 1 Antibody / PLK1, Clone: [PLK1/7122], Mouse, Monoclonal
Artikelnummer:
NSJ-V4413SAF-100UG
Hersteller Artikelnummer:
V4413SAF-100UG
Alternativnummer:
NSJ-V4413SAF-100UG
Hersteller:
NSJ Bioreagents
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
ELISA, IHC-P
Spezies Reaktivität:
Human
Immunogen:
A recombinant fragment of human protein (within amino acids 1-200) was used as the immunogen for the Polo like kinase 1 antibody.
Plk (for polo-like kinase) encodes a serine/threonine kinase that is closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo and CDC5 both code for proteins that are involved in regulating the function of the mitotic spindle. Plk protein accumulates in the cell during the S and G2 phases of the cell cycle, Plk protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Plk expression is detectable in mitotically active tissues such as colon and placenta, as well as in tumors of various origins. It has also been suggested that Plk may serve as a marker of cell proliferation.
