A recombinant fragment (within amino acids 48-321) of human FCER2/CD23 protein was used as the immunogen for the FCER2 antibody.
CD23 (FCER2) is a type II integral membrane glycoprotein that is expressed on mature B cells, monocytes, eosinophils, platelets and dendritic cells. FCER2 is a low affinity IgE receptor that mediates IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. FCER2 associates as an oligomer where cooperative binding of at least two lectin domains is required for high affinity IgE binding to FCER2. It may play a role in antigen presentation by B cells by interacting with CD40. FCER2 has been shown to be associated with the Fyn tyrosine kinase. The truncated molecule can be secreted, then function as a potent mitogenic growth factor. FCER2 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes and on EBV transformed B lymphoblastoid cell lines. FCER2 is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some cases on centroblastic/centrocytic lymphoma.
