Recombinant Cathepsin D Antibody / CTSD, Clone: [CTSD/9613R], Rabbit, Monoclonal
Artikelnummer:
NSJ-V5441-100UG
Hersteller Artikelnummer:
V5441-100UG
Alternativnummer:
NSJ-V5441-100UG
Hersteller:
NSJ Bioreagents
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC-P
Spezies Reaktivität:
Human
Immunogen:
A His-tagged CTSD protein was used as the immunogen for the recombinant Cathepsin D antibody.
Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52kDa preprocathepsin D that is cleaved and glycosylated to form a 48kDa procathepsin D and then further cleaved to produce 34kDa and 14kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimers disease.
